04 September 2018 : Review article
Role of the Wnt/b-Catenin Pathway Inhibitor Sclerostin in Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)Chao Zheng1AE, Huang Ding2AE, Linjun Qin3E, Ali Xiong1EG, Jiulong Wang4DF*, Changqing Yin1AEF
Med Sci Rev 2018; 5:19-24
Sclerostin, an osteocyte-derived biomarker that regulates bone health via inhibition of the Wnt/β-catenin pathway has been widely researched in adynamic bone disease. In recent years, accumulated evidence demonstrates that there exists a dramatic change in sclerostin levels in chronic kidney disease-mineral and bone disorder (CKD-MBD) patients. Also, more investigations have been performed to assess its potential significance in patients with CKD-MBD, which mainly is a systemic disorder of mineral and bone metabolism. This review summarizes the emerging understanding of sclerostin and its role in different pathological and physiological changes of CKD according to 3 aspects – bone metabolism, vascular calcification, and mineral and electrolyte disorder – to discuss and predict its value in clinical settings.
Keywords: Bone Demineralization Technique, Renal Insufficiency, Chronic, renal osteodystrophy
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