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10 April 2018 : Review article  

Properties of Olfactory Ensheathing Cells Conditioned Medium and Its Potential Therapeutic Effect on Spinal Cord Injury: A Review

Zhengchao GaoABEF, Yingjie ZhaoAEF, Yiqun WangEF, Jiantao LiuE, Binbin NiuF, Hui SongE, Su’e ChangAG, Haopeng LiA, Xijing HeAG

DOI: 10.12659/MSRev.909751

Med Sci Rev 2018; 5:1-13


Olfactory ensheathing cells (OECs), a specialized type of glia in the olfactory system, have been extensively investigated because of their ability to promote axonal growth, and they have been successfully used in transplants for treating spinal cord injury (SCI) in animals and humans. Transplantation of OECs has been considered one of the most promising therapeutic strategies for SCI. The neural repair-promoting properties of OECs have been ascertained by a number of important advances both in vitro and in vivo. Recent in vitro and in vivo studies have shown that olfactory ensheathing cells conditioned medium (OECs-CM) can promote axonal regeneration and improve the functional recovery of SCI rats, in a manner similar to that of OECs. Therefore, OECs-CM therapy has been used as a novel cell-free-based therapeutic strategy for SCI. However, the molecular mechanisms of OECs-CM treatment for SCI remain partly speculative. In this article, we summarize the properties of OECs-CM and its potential therapeutic effect on spinal cord injury. A better understanding of the properties of OECs-CM will be beneficial to discover the underlying mechanisms whereby OECs-CM exerts its neural repair-promoting function, and it is important to enable OECs-CM to play a greater role in treating nerve injury.

Keywords: Culture Media, Conditioned, Nerve Regeneration, olfactory bulb, Olfactory Mucosa, Spinal Cord Injuries

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01 September 2023 : Editorial  

Editorial: A Rapid Global Increase in COVID-19 is Due to the Emergence of the EG.5 (Eris) Subvariant of Omicron SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.942244

Med Sci Monit 2023; 29:e942244


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750