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26 April 2016 : Review article  

Evaluation of Treatment with a Combination of Everolimus and Low-Dose Cyclosporine A in De Novo Pediatric Kidney Transplantation Patients: A Systematic Review

Jun WangEF, Nannan GuAB, Mingming YuC, Jingtong ShaD, Hang WuD, Yulong GongC, Haobo ZhuCD, Zheng GeCD, Rugang LuD, Gemg MaBC, Yunfei GuoEG

DOI: 10.12659/MSRev.897492

Med Sci Rev 2016; 3:49-54


The aim of our systematic review was to determine the clinical efficacy, safety, and tolerability of everolimus and low-dose cyclosporine A (CsA) combination treatment in de novo pediatric kidney transplantation. Our electronic literature searches of Medline, Cochrane Central Register of Controlled Trials (CENTRAL) and Embase (updated on May 1st 2015) checked all articles on everolimus and low-dose CSA treatment published in English language. Two authors independently made study selections, data extraction, and analysis. A total of 3 case series and 3 clinical trials were included in our systematic review. The overall incidence rate of borderline changes, biopsy-proven acute rejection, interstitial fibrosis, and tubular atrophy, graft loss and death were 8.21%, 9.00%, 13.43%, 0.75%, and 0%, respectively. The incidence rate of urinary tract infection was 30.83%, but can be well-tolerated by giving proper medical treatment. Other reported severe adverse events, such as lymphocele, wound healing dysfunction, pyrexia, pneumonia, viral infections, were less than 10%. Everolimus and low-dose CsA combination treatment is effective, safe, and well-tolerated in de novo pediatric kidney transplantation. However, an open-label randomized controlled clinical trial will provide an incentive to refine our clinical use of everolimus in children.

Keywords: Cyclosporine, Hospitals, Pediatric, Kidney Transplantation

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01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750