Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

16 October 2015 : Review article  

Randomized Controlled Clinical Trials in Radiation Therapy: Patterns of Publication in the Most Frequently Cited Studies

Carsten NiederABCDEF, Hans GeinitzADEF, Nicolaus H. AndratschkeADEF, Anca L. GrosuADEF

DOI: 10.12659/MSRev.895488

Med Sci Rev 2015; 2:104-110


Background: Landmark research, e.g., randomized controlled clinical trials (RCTs), is often cited frequently. We correlated citations and journal impact factor of frequently cited RCTs published between 2000 and 2004. Material and Methods: The citation database Scopus was used to analyze number of citations. Results: Eighty-one publications were included, which achieved between 12 and 232 citations per year. A broad range of research questions were addressed, e.g., timing of radiotherapy, dose escalation, fractionation, and involved vs. extended field technique. Furthermore, radiotherapy alone was compared to combination treatment. Most RCTs were published in the Journal of Clinical Oncology (JCO), New England Journal of Medicine (NEJM), Lancet and International Journal of Radiation Oncology, Biology and Physics (IJROBP). These 4 journals were analyzed further. The journal with the highest impact factor (NEJM) had published RCTs that acquired significantly more citations than any other journal (median 74.5 per year). The Lancet ranked second, both regarding impact factor and citations (median 37 per year). The JCO (third highest impact factor) had published RCTs that acquired a median of 25 citations, which was not significantly different from that of the IJROBP, which had a much lower impact factor (median 23 citations per year). Ten out of the 11 most frequently cited RCTs were published in the NEJM or Lancet. Conclusions: Few of the most frequently cited publications appeared in journals with impact factor <20. Regarding the remaining studies, journal impact factor did not necessarily reflect citation figures.

Keywords: Radiation Oncology, Radiotherapy

Add Comment 0 Comments


01 September 2023 : Editorial  

Editorial: A Rapid Global Increase in COVID-19 is Due to the Emergence of the EG.5 (Eris) Subvariant of Omicron SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.942244

Med Sci Monit 2023; 29:e942244


In Press

28 Sep 2023 : Clinical Research  

Trends in Hospitalization Duration for Rare Diseases: A Retrospective Analysis of Sarcoidosis, Still's Dise...

Med Sci Monit In Press; DOI: 10.12659/MSM.941536  

27 Sep 2023 : Laboratory Research  

Enhanced Proliferation and Adhesion Marker Gene Expression in Fibroblast Cells: Evaluating the Efficacy of ...

Med Sci Monit In Press; DOI: 10.12659/MSM.941641  

26 Sep 2023 : Clinical Research  

Hypothalamic Injury and Clinical Outcomes in Patients with Post-Traumatic Hyponatremia: A Diffusion Tensor ...

Med Sci Monit In Press; DOI: 10.12659/MSM.942397  

26 Sep 2023 : Clinical Research  

Psychometric Properties of the Polish Version of the FACIT-Sp-12: Assessing Spiritual Well-Being Among Pati...

Med Sci Monit In Press; DOI: 10.12659/MSM.941769  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788


30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750