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07 September 2015 : Review article  

Comparison of Effects of Thiazolidinediones and Metformin on the HOMA Index in Type 2 Diabetics: A Meta-Analysis

Rui WangABCDEF, Ri-bao WeiAG, Na WangB, Meng-jie HuangBC, Yue YangBD, Yue XingB, Zi-cheng WangB

DOI: 10.12659/MSRev.895147

Med Sci Rev 2015; 2:81-91


Background: Insulin resistance(IR) precedes and plays a pivotal role in type 2 diabetes and occurs early in the natural history of the disease. This investigation compared the efficacy of thiazolidinediones(TZDs) and metformin(MET) in the effect of insulin resistance(IR) as assessed using the homeostasis model assessment(HOMA) index in drug-naive type 2 diabetic patients. Material and Methods: We searched the MEDLINE, EMBASE, and Cochrane Library databases to identify studies published before February 2015 that investigated the use of TZDs and MET to determine the effect on the HOMA index in drug-naive type 2 diabetics. Parameters on IR, HbA1c, BMI and waist circumference were collected. Review Manager 5.3 and Stata 12.0 were used to perform the meta-analysis. Fixed and random effects models were applied to various aspects of the meta-analysis, which assessed the therapeutic effects of the two types of drug using the HOMA index in type 2 diabetics. The meta-analysis included nine randomized controlled short trials (12~18 weeks). Results: Participants comparisons before and after treatment with TZDs and MET revealed that TZDs and MET treatments could improve HOMA index and lower FPG, FPI, HbA1c in drug-naive type 2 diabetics with lifestyle intervention. No significant differences in the therapeutic effects of these two types of drug on HOMA index, HbA1c, BMI and waist circumference were observed. Conclusions: On the basis of life intervention, either TZDs or MET might be a good choice in drug-naive type 2 diabetics.

Keywords: Diabetes Mellitus, Type 2, Insulin Resistance, Thiazolidinediones

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01 September 2023 : Editorial  

Editorial: A Rapid Global Increase in COVID-19 is Due to the Emergence of the EG.5 (Eris) Subvariant of Omicron SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.942244

Med Sci Monit 2023; 29:e942244


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750