07 September 2015 : Review article
Comparison of Effects of Thiazolidinediones and Metformin on the HOMA Index in Type 2 Diabetics: A Meta-AnalysisRui WangABCDEF, Ri-bao WeiAG, Na WangB, Meng-jie HuangBC, Yue YangBD, Yue XingB, Zi-cheng WangB
Med Sci Rev 2015; 2:81-91
Background: Insulin resistance(IR) precedes and plays a pivotal role in type 2 diabetes and occurs early in the natural history of the disease. This investigation compared the efficacy of thiazolidinediones(TZDs) and metformin(MET) in the effect of insulin resistance(IR) as assessed using the homeostasis model assessment(HOMA) index in drug-naive type 2 diabetic patients. Material and Methods: We searched the MEDLINE, EMBASE, and Cochrane Library databases to identify studies published before February 2015 that investigated the use of TZDs and MET to determine the effect on the HOMA index in drug-naive type 2 diabetics. Parameters on IR, HbA1c, BMI and waist circumference were collected. Review Manager 5.3 and Stata 12.0 were used to perform the meta-analysis. Fixed and random effects models were applied to various aspects of the meta-analysis, which assessed the therapeutic effects of the two types of drug using the HOMA index in type 2 diabetics. The meta-analysis included nine randomized controlled short trials (12~18 weeks). Results: Participants comparisons before and after treatment with TZDs and MET revealed that TZDs and MET treatments could improve HOMA index and lower FPG, FPI, HbA1c in drug-naive type 2 diabetics with lifestyle intervention. No significant differences in the therapeutic effects of these two types of drug on HOMA index, HbA1c, BMI and waist circumference were observed. Conclusions: On the basis of life intervention, either TZDs or MET might be a good choice in drug-naive type 2 diabetics.
Keywords: Diabetes Mellitus, Type 2, Insulin Resistance, Thiazolidinediones
01 September 2023 : EditorialEditorial: A Rapid Global Increase in COVID-19 is Due to the Emergence of the EG.5 (Eris) Subvariant of Omicron SARS-CoV-2
Med Sci Monit 2023; 29:e942244
28 Sep 2023 : Clinical ResearchTrends in Hospitalization Duration for Rare Diseases: A Retrospective Analysis of Sarcoidosis, Still's Dise...
Med Sci Monit In Press; DOI: 10.12659/MSM.941536
27 Sep 2023 : Laboratory ResearchEnhanced Proliferation and Adhesion Marker Gene Expression in Fibroblast Cells: Evaluating the Efficacy of ...
Med Sci Monit In Press; DOI: 10.12659/MSM.941641
26 Sep 2023 : Clinical ResearchHypothalamic Injury and Clinical Outcomes in Patients with Post-Traumatic Hyponatremia: A Diffusion Tensor ...
Med Sci Monit In Press; DOI: 10.12659/MSM.942397
Most Viewed Current Articles
13 Nov 2021 : Clinical ResearchAcceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...
Med Sci Monit 2021; 27:e932788
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
14 Dec 2022 : Clinical ResearchPrevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels
Med Sci Monit 2022; 28:e937990