Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

13 May 2015 : Review article  

Metalloproteinases – their Role in Inflammatory Processes and Central Nervous System Diseases

Kinga BobińskaABCDEFG

DOI: 10.12659/MSRev.894260

Med Sci Rev 2015; 2:35-40

Abstract

MMPs belong to zinc endopeptidases. MMPs degrade a wide spectrum of extracellular matrix proteins and are constitutively expressed in a large number of cell and tissue types. The physiological role of MMP includes angiogenesis, embryogenesis and tissue remodelling by proliferation, migration, differentiation and adhesion. In pathological processes MMP has been indicated in Alzheimer disease, cancers, and cardiovascular diseases. MMPs degrade numerous receptors on the surface of cells as well as activate and deactivate growth factors, cytokines and chemokines. These processes prove why MMP has been shown to modulate inflammation. Metalloproteinases (MMPs) have a direct and indirect effect on the Blood Brain Barrier (BBB) owing to their role in inflammatory processes. It has also been proved that cardiovascular diseases, brain and heart strokes, multiple sclerosis and cancers are dysfunctions connected with a higher risk of depression onset. It is said that an inflammatory process may be a potential link between the aforementioned diseases and depression. Protein levels of MMPs are corresponding to gene expression and are associated with clinical outcome. Gelatin zymography is one of the most commonly utilised methods for the quantification of MMPs. MMPs are engaged in the pathophysiology of inflammatory processes. In recurrent depressive disorders, inflammation plays the key role not only on the brain tissue level. It has been suggested that inflammation may be associated with depression and cardiovascular dysfunctions. An association between MMP genotype and clinical outcome seems to play the key role in genotyping in clinical practice. Further, MMP detecting and reacting may be considered a possible target for the development of new therapies against disorders of the nervous and vascular systems.

Keywords: Central Nervous System, Depression, Matrix Metalloproteinases

Add Comment 0 Comments

Editorial

01 May 2023 : Editorial  

Editorial: Twenty Years On from Sequencing the Human Genome, Personalized/Precision Oncology Prepares to Meet the Challenges of Checkpoint Inhibitor Therapy

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.940911

Med Sci Monit 2023; 29:e940911

0:00

In Press

31 May 2023 : Review article  

Prevalence, Diagnosis, and Management of Eclampsia and the Need for Improved Maternal Care: A Review

Med Sci Monit In Press; DOI: 10.12659/MSM.939919  

30 May 2023 : Clinical Research  

A Case-Control Study of Cognitive Function in Patients with End-Stage Renal Disease Before and After Hemodi...

Med Sci Monit In Press; DOI: 10.12659/MSM.940409  

30 May 2023 : Review article  

A Review of the Role of the Zebrafish (Danio reiro) in Preclinical and Clinical Models of Biomarker Identif...

Med Sci Monit In Press; DOI: 10.12659/MSM.940550  

30 May 2023 : Database Analysis  

The COVID-19 Crisis and the Incidence of Alcohol-Related Deaths in Poland

Med Sci Monit In Press; DOI: 10.12659/MSM.940904  

Most Viewed Current Articles

13 Nov 2021 : Clinical Research  

Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...

DOI :10.12659/MSM.932788

Med Sci Monit 2021; 27:e932788

0:00

30 Dec 2021 : Clinical Research  

Retrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...

DOI :10.12659/MSM.935379

Med Sci Monit 2021; 27:e935379

08 Mar 2022 : Review article  

A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Man...

DOI :10.12659/MSM.936292

Med Sci Monit 2022; 28:e936292

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750