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Welcome to the Medical Science Review

Medical Science Review (MSR) has developed as an independent title in 2014 as a continuation of highly successful Review Section of the Medical Science Monitor (since 1995). The aim of the Journal is to gather review articles across all medical disciplines, thereby integrating international medical knowledge. Medical Science Review has adopted the Open Access publishing model which enables free access... read more


Published: 2017-04-04

Uninterrupted Aspirin Therapy and Increased Risk of Bleeding After Colonoscopic Polypectomy: A Meta-Analysis

Guangcheng Chen, Chulin Huang

(Department of Gastroenterology, The Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland))

Med Sci Rev 2017; 4:1-6

DOI: 10.12659/MSRev.903614


ABSTRACT: The risk of post-polypectomy bleeding in patients undergoing colonoscopy on uninterrupted aspirin therapy has been a matter of debate for many years.
A systematic literature search was performed in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Chinese Biomedical Literature Database updated on October 2016 for all qualified publications. The search included keywords for aspirin, endoscopic procedure, bleeding, and clinical trials. The selection was not confined regarding types of design or year of publication. Duplicate articles were removed. For each study, the odds ratio and its 95% confidence interval were calculated to assess the association strength between bleeding after colonoscopic polypectomy and uninterrupted use of aspirin.
A total of 5 eligible studies were eventually included. Among these 5 case-control studies, only 1 was prospective, and the other 4 were retrospective. Finally, the analysis shows that uninterrupted using of aspirin increased the risk of post-polypectomy bleeding (OR=1.44, 95% CI=1.06–1.96, P=0.02).
Our meta-analysis shows that uninterrupted aspirin therapy probably increases the risk of bleeding after colonoscopic polypectomy.

Keywords: Aspirin, Colonoscopy, Meta-Analysis as Topic, Postoperative Hemorrhage




Published: 2016-12-20

Use of Somatic Mutation Detection Methods in Cancer


Yang Yang, Tingting Qu, Shuqin Jia

Med Sci Rev 2016; 3:119-126

DOI: 10.12659/MSRev.902012

Published: 2016-09-06

Audiogenic Seizures and Their Importance in Experimental Behavioral Studies: A Review


Ipek Komsuoglu Celikyurt, Esra Isık, Cem Onur Erdolu

Med Sci Rev 2016; 3:110-118

DOI: 10.12659/MSRev.899608